❓WHAT HAPPENED: Scientists have identified a slight increase in shingles risk following COVID booster shots, according to a new study.
👤WHO WAS INVOLVED: Researchers from the University of Groningen in the Netherlands analyzed data from over two million people.
📍WHEN & WHERE: The study was published in the peer-reviewed journal Drug Safety in December 2025.
🎯IMPACT: The U.S. Food and Drug Administration (FDA) is reportedly considering adding a ‘black box’ warning to COVID-19 vaccines to highlight potential side effects.
A study conducted by researchers at the University of Groningen in the Netherlands has found a small but measurable increase in the risk of shingles following COVID booster shots. The study analyzed electronic health records of over two million people aged 12 and older who had received at least one COVID-19 vaccine dose.
The findings revealed a seven percent increase in shingles risk within 28 days of vaccination when all doses were combined, and a 21 percent increase following the third, or booster, dose of mRNA vaccines. Shingles, a painful rash caused by the varicella-zoster virus, is more likely to occur when immune cells are temporarily depleted, which researchers suggest may happen after repeated vaccine doses.
The study also highlighted a 38 percent higher risk of shingles among men who received vector-based vaccines. However, the authors emphasized that these increases are temporary and mostly limited to specific subgroups, with most cases being manageable without hospitalization.
Separate research has linked severe shingles cases to a higher likelihood of developing early-onset dementia, particularly among individuals aged 50 to 65. The U.S. Food and Drug Administration (FDA) is reportedly considering implementing a ‘black box‘ warning on COVID-19 vaccines, its most serious advisory, to inform the public about potential risks.
The study, published in the journal Drug Safety, noted that some countries and territories, including Hong Kong, have reported an increase in shingles cases following mRNA vaccinations.
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