❓WHAT HAPPENED: Representative Julia Letlow (R-LA) announced her U.S. Senate bid against Senator Bill Cassidy (R-LA), following her endorsement by President Donald J. Trump.
👤WHO WAS INVOLVED: Rep. Letlow, Sen. Cassidy, President Trump, and Louisiana Governor Jeff Landry (R).
📍WHEN & WHERE: Letlow announced her decision during a breakfast in Baton Rouge, Louisiana, on Tuesday morning.
🎯IMPACT: The race will likely become one of the more expensive primary contests of the 2026 cycle and is the second serious primary race an incumbent Republican senator faces, with Texas Attorney General Ken Paxton (R) already challenging Senator John Cornyn (R-TX).
Representative Julia Letlow (R-LA) announced Tuesday morning at a breakfast event in Baton Rouge, Louisiana, that she will challenge incumbent Senator Bill Cassidy (R-LA) in the 2026 midterm elections. The announcement comes after President Donald J. Trump announced he would back Letlow’s candidacy in a post on Truth Social this past Saturday.
“Should she decide to enter this Race, Julia Letlow has my Complete and Total Endorsement. RUN, JULIA, RUN!!!” Trump wrote. While Letlow has not yet made any public statements about her Senate bid, her candidacy is expected to receive significant backing from Louisiana Republican leaders, along with President Trump. Months ago, Governor Jeff Landry (R-LA)—a staunch Trump ally—identified Letlow as an ideal challenger to Sen. Cassidy.
While Cassidy has attempted to reposition himself as a soft pro-Trump senator, the Louisiana lawmaker was one of a handful of Republicans to vote to convict President Trump during the 2021 Democrat-led impeachment over the January 6 Capitol protests. “Our Constitution and our country are more important than any one person. I voted to convict President Trump because he is guilty,” Cassidy said at the time.
Additionally, Sen. Cassidy is a top primary target for members of the Make America Healthy Again (MAHA) movement and vaccine skeptics—along with other allies of Department of Health and Human Services (HHS) Secretary Robert F. Kennedy, Jr.
The National Pulse previously reported that between 2019 and 2024, Sen. Cassidy received an estimated $667,000 in political contributions from the pharmaceutical industry. Federal disclosures reveal that an influx of campaign donations began on February 10, 2023, shortly after Cassidy’s appointment as the ranking member of the Senate Health Committee. Contributions from the period included $5,800 from Pfizer CEO Albert Bourla, $5,000 from Eli Lilly CEO David Ricks, $2,900 from Bristol Myers Squibb CEO Giovanni Caforio, and $2,500 from Biogen CEO Christopher Viehbacher, all of whom are members of the Pharmaceutical Research and Manufacturers of America (PhRMA) board.
A reliable Trump vote in the House, Letlow was elected to the House in a 2021 special election after her husband died of COVID complications shortly after winning the congressional seat. Trump’s backing of Letlow pits the White House against the National Republican Senatorial Committee (NRSC), which has endorsed Cassidy as part of its tradition of backing incumbents.
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